Since the BMP-2/BMP-7 ratio in MWF rats correlates with (i) 25-OH-cholecalciferol deficiency, (ii) renal function worsening, and (iii) SBP, DBP, and PWV, we propose that its determination might be of clinical interest and could provide information about the degree of renal and vascular damage in CKD. The gene discussed is BMP7; the disease is chronic kidney disease.