Since the BMP-2/BMP-7 ratio in MWF rats correlates with (i) 25-OH-cholecalciferol deficiency, (ii) renal function worsening, and (iii) SBP, DBP, and PWV, we propose that its determination might be of clinical interest and could provide information about the degree of renal and vascular damage in CKD. This evidence concerns the gene BMP2 and chronic kidney disease.