CNP and heart failure: In the present study, we investigated the effect of AST on hippocampal microglia, their number and properties, the respiratory activity of mitochondria, Ca2+ retention capacity (CRC), mitochondrial swelling, and the change in the content of mPTP regulator proteins such as VDAC, ANT (1/2), CyP-D, CNPase, and ADAP1 in the non-synaptic brain mitochondria isolated from rat after heart failure.