ALOX5 and COVID-19: Concerning the 5-LOX activation state, we report a significant increase in LTB4 plasma levels in COVID-19 and long-COVID patients versus healthy donors (Figure 4A), which seems to be in line with the previously described post-transcriptional activation of an apo-form of 5-LOX, which leads to an active holo-5-LOX able to produce LTB4 in iron overloading conditions [61].