Authors demonstrated that after prolonged (6 days) incubation in the presence of 250 nM JQ1, the malignant pleural mesothelioma (MPM) cells, but not normal non-transformed mesothelial cells (HMC) displayed elevated expression of the “eat-me” signals, calreticulin and ERp57. This evidence concerns the gene PDIA3 and malignant pleural mesothelioma.