PICALM and early-onset autosomal dominant Alzheimer disease: Finally, we examined the effect of BET inhibitor JQ1 on mRNA levels of phagocytosis-related genes which were previously demonstrated to be involved in the pathomechanism of Alzheimer’s disease: Abca7, Bin1, Cd2ap, Cd33, Clu, Cr1l (the murine ortholog of human CR1), Picalm, Rab10, Rin3, Scara3, Trem2, and Zyx.