Simply stated, the sympathetic nervous system (SNS) induces the release of renin, also known as angiotensinogenase, from the kidney, which then hydrolyzes angiotensinogen to produce angiotensin I (Ang I), which is then hydrolyzed by lung angiotensin-converting enzymes (ACEs), yielding angiotensin II (Ang II), a key factor in hypertension and myocardial remodeling. The gene discussed is REN; the disease is Hypertension.