Most intriguingly, the TyG index (a non-insulin-based index) has been demonstrated to have a good closeness of agreement to the gold standard, the hyperinsulinemic–euglycemic clamp, in estimating the severity of insulin-resistance and to be equal—or even superior—to the HOMA-IR index (homeostatic model assessment of insulin resistance) [17,22]. This evidence concerns the gene INS and Insulin resistance.