The risk of developing TB or dying was significantly higher in PLHIV on WHO stage III and above at baseline [12,13,14,16,17,18,22], male [12,13,14,22], with a CD4 count of less than a 350 cell count/μL and those with opportunistic infections [15,16,17,18,21,22], children with delayed motor development [21] who did not take cotrimoxazole preventive therapy [18,21,22], use anti-pain [22], and have a hemoglobin level less than 10 mg/dL [16,21,22]. The gene discussed is CD4; the disease is Opportunistic infection.