Figure 1 represents the area under ROC curve (AUC) as 0.870, which includes a combination of seven identified risks factors of depression (low education levels, physical inactivity, stroke, low serum albumin levels, CKD Stages 3–4, macroalbuminuria, and a poor QOL). As shown in Figure 2, the AUC of those seven risk factors (high education levels, physical inactivity, neuropathy, retinopathy, low hemoglobin levels, CKD stages 3–4, and a poor QOL) combined for predicting anxiety was 0.862. The gene discussed is ALB; the disease is retinal disorder.