Although other TIMP3 genetic polymorphisms may have limited direct effects on biochemical recurrence of prostate cancer, both TIMP3 rs9619311 and rs9862 genetic polymorphisms can be used as important predictors of prostate cancer prognosis, and among them, the rs9619311 gene polymorphism can also be used as a pivotal predictor of biochemical recurrence of prostate cancer. This evidence concerns the gene TIMP3 and Familial prostate cancer.