There is numerous evidence that has shown that TIMP3 expression is associated with the development and prognosis of multiple human cancers, such as non-small cell lung cancer, colorectal cancer, hepatocellular carcinoma, uterine cervical cancer, and head and neck squamous cell carcinomas, etc. [15,16,17,18,19,20,21,22]. This evidence concerns the gene TIMP3 and hepatocellular carcinoma.