Aerobic physical exercise induces apoptosis, as demonstrated in breast cancer murine models [96,107], in terms of increased expression of Bax and caspase-3 [107]; anaerobic training increases the rate of tumor cells’ apoptosis in male rats (two folds higher compared to sedentary rats, paralleled by an increase of Bax and reduction in Bcl-2 expression) [37]. Here, BAX is linked to neoplasm.