Another clinical investigation reports the significant impact of promoter methylation of certain genes, namely cyclin D2 (CCND2), twist family bHLH transcription factor 1 (TWIST1), adenomatous polyposis coli (APC), and high in normal-1 (HIN1), on survival after breast cancer diagnosis, and the inverse relationship between physical activity before diagnosis and breast cancer mortality. This evidence concerns the gene APC and breast cancer.