As stated above, larger prospective studies might allow addressing several open issues, including the advantage of [68Ga]Ga-PSMA-11 PET/CT as the guide for MDT alone vs. MDT + systemic therapy, for hormone-sensitive vs. castration-resistant PCa patients and PCa patients with different PSA serum levels at baseline. The gene discussed is KLK3; the disease is posterior cortical atrophy.