Even though a large amount of data demonstrated the superior diagnostic accuracy of PSMA-targeted radiotracers compared to either [11C]C-choline or [18F]F-Fluorocholine in the restaging of PCa with low PSA circulating levels [25], no clear superiority has been identified for patients with higher PSA serum levels [25] or with late-stage castration-resistant disease [26]. Here, KLK3 is linked to posterior cortical atrophy.