Accordingly, the cardioprotective effects of coadministration of numerous agents, including the neurohormonal blocking drugs used in the standard management of heart failure (HF), namely angiotensin-converting enzyme inhibitors (ACEi), angiotensin II receptor blockers (ARB), beta-adrenergic receptor antagonists (BB), and aldosterone antagonists, were explored in preclinical and clinical studies [6,7]. This evidence concerns the gene ACE and hydrops fetalis.