This meta-analysis suggests that BRCA1 and BRCA2 occur in PCa Ashkenazi with a similar prevalence; moreover, the prevalence of germline founder variants presents a different frequency in PCa in comparison to BC, in particular with 6176delT (BRCA2) and 185delAG (BRCA1) variants. This evidence concerns the gene BRCA2 and posterior cortical atrophy.