TERT and hepatocellular carcinoma: Mutations in TP53, TERT promoter, IDH1/2 and AXIN 1, which all may also be observed in HCC and/or iCCA, were the most frequent alterations of cHCC-CCA and could be observed in 45.3–80%, 23–70%, 0–11.8% and 10% of studied cases, respectively [9,56,57].