In addition, Deng et al. [61] demonstrated that the NCL/miR-221/NFκB/DNMT1 axis is a novel molecular pathway contributing to AML leukemogenesis and prepared a nuclear localization signaling peptide targeted gold nanoparticle co-loaded with anti-221 and AS1411 (NPsN-AS1411/a221). This evidence concerns the gene DNMT1 and acute myeloid leukemia.