NOX-A12 is an RNA oligonucleotide in L-configuration (Spiegelmer) that binds and neutralizes the chemokine CXCL12 with high affinity and specificity, The results of Weisberg et al. showed that the combination of NOX-A12 and TKIs was able to block CXCL12-induced migration of BCR-ABL-positive leukemia (e.g., CML) cells more effectively in vitro to promote the treatment of cancer, and the same results were obtained in vivo experiments in CML model mice [101]. The gene discussed is ABL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.