Exosomal lncRNA SNHG7 secreted from lung adenocarcinoma (LUAD) cells is transferred to macrophages, which activates the phosphatidylinositol 3-kinase (PI3K)/AKT pathway and induces the phosphatase and tensin homolog (PTEN) degradation by recruiting cullin 4A, thus accelerating M2 polarization. Here, PTEN is linked to lung adenocarcinoma.