TNFRSF4 and neoplasm: Some of these biomarkers are immunosuppressive or have pro-tumor activity such as PD-L1, IL17RE, LAG-3, IDO-1, TIM-3 whereas others have antitumor activity such as CD8+ T-cells, OX40, CXCL9 and others have a mixed role such as IFN-G.