PKM and cancer: In addition, c-Myc, glucose transporter 1 (GLUT1), and lactate exporter monocarboxylate transporter 4 (MCT4), as the downstream protein of β-catenin, can be regulated [6,7]; therefore, PKM2-overexpression leads to increased glycolysis by increasing glucose input and lactate acid output, which speeds cancer progression [8,9].