In contrast to the P0 tumor, Wilms tumor HT139 PDX passages display relatively decreased levels of the downstream effector for mTORC1, p70S6K, which is phosphorylated at serine 371 (S371) [99], as well as relatively increased cofilin phosphorylated at serine 3, which was previously demonstrated to contribute to cancer metastasis [100,101,102,103] and be associated with human glomerular disease [103]. The gene discussed is RPS6KB1; the disease is glomerular disorder.