A repeating peptide epitope of MUC16, a mucosal protein, known as cancer antigen 125 (CA125) is overexpressed in adult cancers, such as ovarian, lung, and pancreatic cancer, where it contributes to immunoprotection, metastasis, oncogenic signaling, and disease [86,87]. This evidence concerns the gene MUC16 and familial pancreatic carcinoma.