A statistically significant association between the low LMR and the expression of PD-L1 was reported in patients with HCC, hypothesizing that increased levels of monocyte-derived cells in the HCC microenvironment can be suspected if a low LMR is detected, resulting in an increased PD-L1 expression level of HCC cells in response to cytokines secreted by the immune cells [86]. This evidence concerns the gene CD274 and hepatocellular carcinoma.