TPI1 and glioblastoma: Interestingly, LLL12 treatment exhibited downregulation of phosphoglycerate mutase 1 (PGAM1), triosephosphate isomerase (TPI), adaptor molecule cysteine-rich receptor-like protein kinase 2 (CRK2), basic transcription factor 3 (BTF3), and protein DJ-1 (PARK7), which suggested that these targets may serve as prognostic or predictive markers in GBM [223].