Prostate Specific Membrane Antigen-Positron Emissions Tomography (PSMA-PET) represents the most accurate novel imaging procedure to restage PCa [5], due to its high diagnostic accuracy to correctly detect and localize PCa lesions [6] even in the early stage of disease, when the tumor burden and prostate specific antigen (PSA) levels are low [7]. This evidence concerns the gene KLK3 and posterior cortical atrophy.