Positive PSMA-PET (HR 2.37; 95% CI 1.60–3.50), pT3b-pT4 (HR = 2.03; 95% CI: 1.26–3.26) and ADT at salvage treatment (HR = 0.54; 95% CI 0.37–0.78) were independent predictors of metastatic disease (all p ≤ 0.003; Table 3). The gene discussed is FOLH1; the disease is metastatic neoplasm.