No consenting members of branch 8 carried either the MSH2 or MSH6 variant, yet three members had prior cancer diagnoses (Figure 1), including diagnoses of bilateral ovarian cancer in a female aged 65 years in II.9, non-Hodgkin’s lymphoma (NHL) at age 52 years in one of her daughters (III.24), and skin basal cell carcinoma at age 52 and 53 years in another daughter (III.26). The gene discussed is MSH2; the disease is ovarian carcinoma.