A multitude of VUS in cancer-relevant genes was found but the only variant with a clear association with elevated cancer risk was the heterozygous loss-of-function frameshift variant MC1R c.86dupA (p.Asn29Lysfs*14; rs796296176), which has been associated with increased risk for skin cancers [29] but not ovarian cancer. The gene discussed is MC1R; the disease is ovarian carcinoma.