When polyps were included with first cancer occurrence, the cumulative risk for pre/neoplasia onset was also significant (P=0.007) between the groups of carriers of MSH2 c.2006G>T alone (mean age 49.5 years with 95% CI, 45.1–53.9), MSH6 c.3936_4001+8dup (intronic) alone (mean age 54.7 years with 95% CI, 51.2–58.1), both variants (mean age 52.5 years with 95% CI, 51.4–57.1), and non-carriers (mean age 61.5 years with 95% CI, 57.3-65.8) (Figure 3B). This evidence concerns the gene MSH2 and neoplasm.