MSH6 and neoplasm: To assess the risk for cancer onset associated with carriage of either MSH2 c.2006G>T or MSH6 c.3936_4001+8dup (Intronic) or both, we plotted Kaplan–Meier curves of (i) first onset of any cancer, and (ii) first onset of any cancer or colorectal polyp(s) pooled (pre/neoplasia) among segregated groups of confirmed/obligate carriers of MSH2 c.2006G>T alone (n = 26), MSH6 c.3936_4001+8dup (intronic) alone (n = 7), both variants (n = 4), and non-carriers of either variant (n = 27) (Figure 3).