A cousin in branch 2 (III.2, Figure 1) who had developed breast cancer at age 46 years and endometrial cancer at age 60 years subsequently underwent genetic testing of the BRCA1/2 and MMR genes in 2010 in which the MSH2 c.2006G>T variant was identified and again reported as a VUS. The gene discussed is MSH2; the disease is endometrial cancer.