MSH2 and cancer: No consenting members of branch 8 carried either the MSH2 or MSH6 variant, yet three members had prior cancer diagnoses (Figure 1), including diagnoses of bilateral ovarian cancer in a female aged 65 years in II.9, non-Hodgkin’s lymphoma (NHL) at age 52 years in one of her daughters (III.24), and skin basal cell carcinoma at age 52 and 53 years in another daughter (III.26).