Prior to examining the influence of hepcidin, IL-6, and TNF-α on CBC parameters, we investigated the potential impact of subtype and stage of lung cancer, type and extent of surgery that patient underwent, presence of inflammation in the tumour environment (observed in the tumour histopathological examination as inflammatory infiltration next to dust deposition and necrosis), patients’ smoking status, and underlying lung diseases and other comorbidities on the values of CBC parameters in both women and men. This evidence concerns the gene TNF and lung cancer.