Therefore, the main objectives of this study were: (i) to explore the hypothesis that apoptosis and autophagy pathways can be modulated by one of the most studied SCFAs, propionate and (ii) to elucidate whether and how PPAR-γ is involved in these changes by affecting tumor progression in GBM cells and an in vivo xenograft model. This evidence concerns the gene PPARG and glioblastoma.