PTGS2 and cancer: Peroxisome proliferator-activated receptor gamma (PPAR-γ), a member of the nuclear receptor family of ligand-activated transcription factors regulates gene expression of multiple signaling pathways including B-cell lymphoma 2 (BCL-2), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), tumor suppressor p53 (p53), and cyclooxygenase-2 (COX-2) mediators that can regulate different diseases including cancers [17].