Tumor samples from mice treated with the PPAR-γ antagonist GW9662 and SP at the doses of 30 and 100 mg/kg (Figure 8) showed similar expression levels of Ki-67 as GBM mice demonstrating that the reduction of Ki-67 protein expression by SP could be mediated by the PPAR-γ signaling pathway. This evidence concerns the gene MKI67 and glioblastoma.