They have also observed that a high TMB is associated with better clinical outcomes of ovarian cancer and have suggested that high TMB can induce the activation of antitumor immune cells in ovarian cancer due to higher infiltrating activated memory CD4+ T cells, follicle-assisted T cells, and M1 macrophages, which play an essential role in antitumor activity [45]. This evidence concerns the gene CD4 and ovarian carcinoma.