In lung cancer where invasive methods like transbronchial needle aspiration or transthoracic biopsy are used as the diagnosis methods, sEV markers like CD151, CD171, and tetraspanin 8 were identified as a combined diagnostic marker in 276 Non-small cell lung carcinoma (NSCLC) patients [20]. This evidence concerns the gene L1CAM and non-small cell lung carcinoma.