Further examination of the statistical significance between two of these three cohorts showed that GM-CSF, G-CSF, eotaxin, IL-1b, and IL-10 were enriched in the control cohort (Figure 4B); TNF-a, IL17A, MIP-1b, IL-15, RANTES, PDGF-AB/BB, and FGF-2 were enriched in the LC group (Figure 4C); and IL-8 and VEGF-A were enriched in the HCC cohort (Figure 4D). This evidence concerns the gene CSF2 and laryngotracheoesophageal cleft.