Additionally, network features unique to LC or HCC were also identified, including the enterobacterial genera Succinatimonas and Enterobacter; the enterovirus Escherichia virus ECBP5 and uncultured Mediterranean phage uvMED; the plasma cytokines/chemokines IL-1b, MCP-1, IL-10, and FGF-2 for LC; the gut bacterial genera Ruminococcus gnavus group and Oxalobacter; the plasma metabolites threonine, leucine, and methionine; and the plasma cytokines/chemokines IL-17A, MIP-1b, and IL-8 for HCC. Here, CXCL8 is linked to laryngotracheoesophageal cleft.