The median of tumour centre and invasive margin CD3+ and CD8+ densities had strong positive correlation with immune cell PD-1 expression in tumour centre (rs = 0.449; p < 0.001) and invasive margin (rs = 0.595; p < 0.001), moderate positive correlation with immune cell PD-L1 expression (rs = 0.361; p = 0.005) but no significant correlation with tumour cell PD-L1 expression (rs = 0.221; p = 0.096) (Table S1). Here, PDCD1 is linked to neoplasm.