We found that genes affected by miR-34 were significantly associated with signatures of advanced neuroblastoma, p53 mutation, 1p36 LOH in neuroblastoma, poor clinical outcome, recurrent disease and metastasis, and target genes of PRC2 (EZH2, SUZ12) components (Figure 1E), suggesting that miR-34 is engaged in regulating a variety of pathways including EZH2 target genes. This evidence concerns the gene EZH2 and neuroblastoma.