MYCN and neuroblastoma: Since we found the synergistic effect when neuroblastoma cells were treated with combination of YM155 with EZH2 inhibitors, we also tested other combinations of inhibitors against targets in the 27-gene signature (AURKA inhibitor MLN8237, MELK inhibitor OTS167, and TTK inhibitor AZ3146), in two different neuroblastoma cell lines BE2C (with MYCN amplification) and SKNSH (without MYCN amplification).