However, the combination of EZH2 inhibitors and 10 nM of YM155 rapidly killed BE2C cells (Figure 3D) and other tested neuroblastoma cell lines NB1691 and SKNAS, and a glioma cell line SJG2 (Figure S2A–C), although each single agent had no obvious cytotoxicity. Here, EZH2 is linked to neuroblastoma.