While ST2/IL-33R is used as an additional stratification factor for HF, revealing cardiac stress and fibrosis [25,26], GDF-15 plays a double role: a cardioprotective role in HF, reducing recruitment of polymorphonuclear cells that contribute to cardiac tissue destruction, and a function as a diagnostic and prognostic factor in cancer development and progression [27]. Here, IL1RL1 is linked to hydrops fetalis.