These findings indicate that impairment of STIM1 glycosylation attenuates the activation of caspase-3 in non-tumoral cells, while in breast cancer cells, TG-evoked caspase-3 activation, which was significantly smaller than in non-tumoral cells, was unaffected by impairment of STIM1 N-linked glycosylation. The gene discussed is CASP3; the disease is breast carcinoma.