In contrast to STIM1 and Orai1, Orai3 has no N-glycosylation consensus motifs [23]; therefore, we have focused our studies in the functional role of STIM1 and Orai1 glycosylation in SOCE in the breast cancer cell types as compared to MCF10A breast epithelial cells. This evidence concerns the gene STIM1 and breast carcinoma.