PNPLA3 and cancer: The germline genetic testing was limited to the 226 cancer-predisposition genes included in the CZECANCA panel, which was designed for the analysis of cancer predisposition but does not cover some of the known cirrhosis-predisposing genes (i.e., APOB, HFE, PNPLA3, SERPINA1) [43,44,45,46,47].