MET and hepatocellular carcinoma: This bears caution to the thermal impact of RFA, as some studies have reported a 25–39% increase in distant new tumors in patients being treated for HCC [98,99] combination of RFA with drugs, such as c-Met inhibitors (c-Met is involved in several signaling pathways such as PI3k/AKT, Ras/MAPK, JAK/STAT, and VEGF) could block distant metastasis of liver cancer [99,100,101].