TLR4 and colorectal carcinoma: F. nucleatum promoted CRC resistance to chemotherapy by orchestrating Toll-like receptors 4-Myeloid differentiation factor 88 (TLR4-MYD88) innate immune signaling pathway, specific miRNAs (genomic loss of miR-18a* and miR-4802) and autophagy elements (ULK1/ATG7 autophagy network) [108].