ERBB2 and urinary bladder cancer: They further analyzed seven bladder cancer genes that were most mutated (CDKN2A, FGFR3, proliferator-activated receptor gamma (PPARG), human epidermal growth factor receptor 2 (HER2; ERBB2), TP53, E2F3 and RB1), and generated comprehensive profiles of their genomic alterations for each of the above subtypes [8].