Recently, Ma et al. found that the lncRNA lncMX1-215 inhibits PD-L1 and galectin-9 expression in head and neck squamous cell carcinoma cells by interrupting GCN5-mediated H3K27 acetylation (an activating mark), and that its overexpression dramatically lowers tumor cell growth and metastasis in vitro and in vivo [150]. The gene discussed is CD274; the disease is neoplasm.