In M3 module, “Cell adhesion molecules”, “Hematopoietic cell lineage”, “Pathway in cancer” and “Rap1 signaling pathway” were the major signaling cascades, “Proteoglycans in cancer”, “PI3K/AKT signaling pathway”, “Complement coagulation cascade” and “ECM-receptor interaction” were involved in M4 module, while “Cholesterol metabolism”, “Glycolipid metabolism”, “MAPK signaling pathway” and “PPAR signaling pathway” were the main pathways in M5 module (Figure 6g–j and Figure S15; Table S20–S23). Here, PIK3CA is linked to cancer.