Ferrari et al. [56] proved that vandetanib induced apoptosis and significantly inhibited the proliferation, migration, and invasion ability of ATC cells; it inhibited EGFR, AKT, and ERK 1/2 phosphorylation and down-regulated cyclin D1 expression in ATC cells, and prevented tumor growth, microvessel density, and VEGF-A expression in 8305C tumor tissues of nude mice. This evidence concerns the gene AKT1 and neoplasm.