For example, there is a higher incidence of neurofibromatosis 1 (NF1) mutations [5,10], unusual RAS mutations [10,16], and a larger population of H3K27M mutated tumors within this cohort [5], otherwise known as grade 4 diffuse midline glioma (DMG) [22,23,24]. The gene discussed is NF1; the disease is diffuse midline glioma.