Meanwhile, as depicted in Figure 7C,D, IFNAR1 was co-expressed with both CD4 and CD8 molecules, indicating that the expression of IFNAR1 is closely related to the infiltration of CD4+ T and CD8+ T cells, proving that IFNAR1 is a key mediator in promoting immune activation in ccRCC. This evidence concerns the gene CD8A and nonpapillary renal cell carcinoma.