IRS1 and non-small cell lung carcinoma: However, our results showed that LARS1 activated ATK, different from other studies demonstrating that LARS1 expression is inversely related to p-AKT in non-small cell lung cancer cell lines and tissues [19] and that LARS1 inhibits myogenic differentiation through the Rag-mTORC1 pathway and subsequent inhibition of the IRS1-PI3K-AKT pathway [36].