Altogether, these results implicate that PGC-1α regulates cell proliferation and invasion through modulation of the LARS1/AKT/GSK3β/β-catenin axis and that LARS1 might be a potential therapeutic target for PGC-1α-overexpressing human colorectal cancer as depicted in a schematic diagram (Figure 7). Here, LARS1 is linked to colorectal cancer.