To confirm whether PGC-1α regulates the expression levels of LARS1, p-AKT, p-GSK-3β, p-mTOR, p-S6K1, p-4EBP1, β-catenin, c-Myc, cyclin D1, and vimentin in other colorectal cancer HT-29 and SNU-C4 cells, we performed qRT-PCR and Western blot analysis. The gene discussed is EIF4EBP1; the disease is colorectal cancer.