CDK4 and thyroid cancer: Additionally, in the TT human thyroid cancer cell line, ferulic acid exhibited anti-carcinogenesis activity through decreasing the expression of novel gene URG4/URGCP, CCND1, CDK4, CDK6, BCL2, MMP2, and MMP9 and increasing the expression of p53, Poly(ADP-ribose) polymerase (PARP), PUMA, NOXA, BAX, BID, caspase-3 and -9, and TIMP1 genes significantly.