Zoni et al. found that miR-25 is expressed at low levels in normal and transformed prostate stem cells but is rapidly upregulated upon luminal differentiation, leading to the downregulation of α6- and αV-integrins and thereby inhibiting invasive properties and PCa cell extravasation of tumor stem/progenitor cell subpopulations [166]. The gene discussed is TWF1; the disease is neoplasm.