Among these tumors, at the first stage, we collected a group of gliomas with low proliferative activity and a Ki-67 labeling index (LI) less than 5%, corresponding to diffuse glioma, grade 2; that is, this group can be considered an early stage of development of glioblastoma with low proliferative activity and before the appearance of its traditional pathohistological characteristics [22,23]. This evidence concerns the gene MKI67 and glioblastoma.