In particular, in relation to diffuse gliomas, IDH-mut, it was shown by using single-cell RNA sequencing that astrocytomas and oligodendrogliomas are functionally similar to a large extent: populations of the so-called astrocyte-like cells (AC-like) and oligodendrocyte-progenitor-like cells (OPC-like) have almost parity content. The gene discussed is IDH2; the disease is astrocytoma (excluding glioblastoma).