The volcano plot of these data exhibited robust ERBB2 whole transcriptomic changes in the CRC cell lines; HCT116 (1774 DEGs—730 upregulated and 1044 downregulated) and HT29 (1289 DEGs—430 upregulated and 859 downregulated) compared to the normal colon cell lines CCD33 (160 DEGs) and CCD841 (312 DEGs), (Supplementary Figure S3). Here, ERBB2 is linked to colorectal carcinoma.