Another family member of the NKL, NKX2-1, has been reported to mediate p53-induced tumor suppression [47,48,49,50], Indeed, in the context of CRC, NKX2-5 functions as a conditional tumor suppressor gene via activating the p53-mediated p21WAF1/CIP1 expression [51]. This evidence concerns the gene TP53 and neoplasm.