Additionally, the unsupervised hierarchical clustering analysis based on the total DEGs showed that HER2+ and HER2− CRC-patients are, respectively, clustered as a single branch, further confirming the distinct transcriptional profiling between HER2+ and HER2− CRC-patients (Figure 4C, Supplementary Figure S7A). The gene discussed is ERBB2; the disease is colorectal carcinoma.