However, this shortcoming is potentially offset to a large extent by three facts—(a) our analysis also involved HER2− and HER2+ patient samples, which are a better model compared to any of the homogeneous cell line models; (b) our usage of two different CRC cell lines and two normal colon cell lines; and (c) our observation that similar pathways were being enriched when the patient samples and the HER2-overexpressing cell lines were compared. Here, ERBB2 is linked to colorectal carcinoma.