PRKCI and renal cell carcinoma: Additionally, the Caki-1 cell line, a metastatic cell derived from RCC, is the most malignant cell in RCC cell lines [17] and cloud release circ-PRKCI to RCC cells with low metastasis potential in an exosome manner thus enhanced the proliferation, migration, and invasion of RCC cells, while it inhibited their apoptosis.