In tumors with a high frequency of NTRK rearrangements, such as infantile fibrosarcoma, congenital mesoblastic nephroma, and secretory breast carcinoma, NTRK1, NTRK2, and NTRK3 break-apart probes have been routinely used for the triple detection of FISH. Here, NTRK3 is linked to congenital mesoblastic nephroma.