Altered expression and function of the molecular components of SOCE include not only CRAC channel components, such as Orai1 and Orai3, but also other Ca2+ ion channels, for instance, the canonical transient receptor potential channels, which have been found in breast cancer (TRPC1 and TRPC6) [104] and ovarian cancer (TRPC1, TRPC3, TRPC4, TRPC6) [263]. This evidence concerns the gene ORAI1 and breast cancer.