The two major oncogenic pathways [22] that have a central role in the development of the different cancer hallmarks are the rat sarcoma virus—extracellular-signal-regulated kinase (Ras-ERK)—and phosphoinositide 3-kinase (PI3K)-Akt (Akt, also known as protein kinase B, PKB) pathways. This evidence concerns the gene PTK2B and cancer.