Supportively, downregulation of STIM1 and/or Orai1 results in cell cycle arrest at either G0/G1 (glioblastoma [256]), G1/S (cervical [274], gastric [53], cancer) or G2/M transitions (cervical [248], esophageal cancer [255]) due to altered expression of corresponding cyclins, cyclin-dependent kinases, and cell cycle division phosphatases (G1/S: cyclin D1/CDK4 [53,88]; cyclin E/CDK2 [274], cdc25 [248]; G2/M: cyclin B1/cdc2 [255]), and/or proliferation inhibitors ((p. 21 [248]), (p. 27 [255])). The gene discussed is STIM1; the disease is cancer.