In several cancer cell types, it is associated with the downregulation of common epithelial genes (cytokeratins, E-cadherin) and the upregulation of mesenchymal markers (vimentin, fibronectin, N-cadherin, and metastasis-associated in colon cancer-1 (MACC-1)) [42,44,45,46,47,48,49,50,51,52,53] (Figure 1C, Top). Here, FN1 is linked to cancer.