Since we observed that STIM1 binding to Orai1 reduces the co-localization with SK3 in HEK293 cells [343], it might be interesting to determine whether and how endogenous as well as overexpressed STIM1 affect the co-localization and interplay of SK3 and Orai1 in colon cancer cells. The gene discussed is ORAI1; the disease is colonic neoplasm.