TGFB1 and renal cell carcinoma: A previous study by Zhang and coworkers demonstrated that RCC cell-derived sEVs promote the transformation of macrophages to the M2 phenotype, increase the expression of cytokines (such as TGFβ1), enhance the phagocytic ability of macrophages, and induce angiogenesis in RCC by transferring lncARSR, thereby promoting the occurrence and development of RCC [49].