Li and coworkers found that BC cells in a nutrient-deficient environment secreted sEVs containing glutamine-fructose-6-phosphate aminotransferase 1 (GFAT1) to enhance O-GlcNAcylation in endothelial cells, thus promoting angiogenesis, which indicates a new research direction for developing anti-angiogenic treatments in BC [53]. Here, GFPT1 is linked to breast cancer.